Health Testing
The Parson Russell Terrier has it's health issues just like any other breed. Reputable breeders will do their best to avoid these issues and will test their breeding stock whenever possible. Please consider this when selecting a breeder. Most breeders will document their results and some are involved with the Canine Health Information Center (CHIC), run by the Orthopedic Foundation for Animals in the US. Check and see if the breeder is BEAR (hearing test) and CERF (eye test for some issues) at least.
Primary Lens Luxation (PLL)
(Used with permission from the Parson Russell Terrier Club - UK)
Testing for Primary Lens Luxation - The Animal Health Trust
Primary Lens Luxation (PLL) is a well-recognised, painful and blinding inherited eye condition that affects many breeds of dog. In affected dogs the zonular fibres that support the lens breakdown or disintegrate, causing the lens to fall into the wrong position within the eye. If the lens falls into the anterior chamber of the eye glaucoma and loss of vision can quickly result.
Scientists at the AHT have identified a mutation that is associated with the development of PLL in several breeds of dog. The DNA test we are now offering examines the DNA from each dog being tested for the presence or absence of this precise mutation. It is thus a mutation-based test™ and not a linkage-based test™.
Breeders will be sent results identifying their dog as belonging to one of three categories:
CLEAR: these dogs have two normal copies of DNA. Our research has demonstrated clear dogs will not develop PLL as a result of the mutation we are testing for, although we cannot exclude the possibility they might develop PLL due to other causes, such as trauma or the effects of other, unidentified mutations.
CARRIER: these dogs have one copy of the mutation and one normal copy of DNA. Our research has demonstrated that carriers have a very low risk of developing PLL. The majority of carriers do not develop PLL during their lives but a small percentage do. We currently estimate that between 2% – 20% of carriers will develop the condition, although we believe the true percentage is nearer to 2% than 20%. We do not currently know why some carriers develop the condition whereas the majority do not, and we advise that all carriers have their eyes examined by a veterinary ophthalmologist every 6- 12 months, from the age of 2, throughout their entire lives.
GENETICALLY AFFECTED: these dogs have two copies of the mutation and will almost certainly develop PLL during their lifetime. We advise that all genetically affected dogs have their eyes examined by a veterinary ophthalmologist every 6 months, from the age of 18 months, so the clinical signs of PLL are detected as early as possible.
Breeding Advice
Our research has also demonstrated that the frequency of the PLL mutation is extremely high in most breeds. This means that allowing only CLEAR dogs to breed could have a devastating effect on breed diversity and substantially increase the likelihood of new inherited diseases emerging. Therefore, we strongly advise breeders to consider all their dogs for breeding, regardless of their PLL genotype. GENETICALLY AFFECTED and CARRIER dogs can be bred with, but should only be bred to DNA tested, CLEAR dogs. All puppies from any litter that has at least one CARRIER parent should be DNA tested, so that the CARRIERS can be identified and followed clinically throughout their lives. This practise should be followed for at least one or two generations, to allow the PLL mutation to be slowly eliminated from the population without severely reducing the genetic diversity of breeds at risk.
Samples submitted should be cheek swabs (a non-invasive sampling method) obtainable from the Animal Health Trust. Samples should be sent together with a completed DNA Testing form and payment for each sample to
Genetic Services, Animal Health Trust, Lanwades Park, Kentford, Newmarket, Suffolk CB8 7UU.
Kits for taking cheek swabs are available by phoning +44 (0)1638 555621 or via e-mail to swabrequest@aht.org.uk. The price of the test is £40, which includes both VAT and the cost of the sampling kit.
Further information can be obtained by e-mailing dnatesting@aht.org.uk.
More Information On Testing In North America
http://www.offa.org/dnatesting/index.html
http://www.caninegeneticdiseases.net/GLX/mainGLX.htm
CERF Testing
http://www.vmdb.org/history.html
BAER Testing
http://www.offa.org/deaf_baer.html
Patella Testing